Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice
Critical Care2009Vol. 13(1), pp. R1–R1
Citations Over TimeTop 1% of 2009 papers
Esther K. Wolthuis, Alexander P. J. Vlaar, Goda Choi, Joris J. T. H. Roelofs, Nicole P. Juffermans, Marcus J. Schultz
Abstract
MV induces VILI, in the absence of a priming pulmonary insult and even with use of relevant (least injurious) ventilator settings. This model offers opportunities to study the pathophysiological mechanisms behind VILI and the contribution of MV to lung injury in the absence of pre-existing lung injury.
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