Infection rates among cooled patients post cardiac arrest
Citations Over Time
Abstract
We conducted a retrospective study looking at infection rates in patients treated with therapeutic hypothermia (TH) following cardiac arrest who were admitted to the ICU of the Bristol Royal Infirmary since May 2007. TH is recommended in all patients presenting with persistent coma following cardiac arrest. One complication of TH is the risk of infection. Hypothermia suppresses the immune system by inhibiting the release of proinflammatory cytokines and by suppressing the chemotactic migration of leukocytes and phagocytosis [1]. In patients with traumatic brain injury, TH for more than 48 hours is associated with a higher risk of infection, but not if the period of hypothermia is less than 24 hours [2]. In patients following cardiac arrest, infection is common, reported in up to 73% of patients [3].
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