Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery
Critical Care2010Vol. 14(5), pp. R181–R181
Citations Over TimeTop 10% of 2010 papers
Paula Dennen, Christopher Altmann, Jonathan L. Kaufman, Christina L. Klein, Ana Andrés-Hernando, Nilesh Ahuja, Charles L. Edelstein, Melissa A. Cadnapaphornchai, Angela Keniston, Sarah Faubel
Abstract
Urine IL-6 increases early in patients with AKI. Animal studies demonstrate that failure of proximal tubule metabolism of IL-6 results in increased serum and urine IL-6. Impaired IL-6 metabolism leading to increased serum IL-6 may contribute to the deleterious systemic effects and increased mortality associated with AKI.
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