Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma
Critical Care2010Vol. 14(6), pp. R208–R208
Citations Over TimeTop 10% of 2010 papers
A. Chéron, Bernard Floccard, Bernard Allaouchiche, Caroline Guignant, Françoise Poitevin, Christophe Malcus, Jullien Crozon, Alexandre Faure, C. Guillaumé, Guillaume Marcotte, Alexandre Vulliez, Olivier Monneuse, Guillaume Monneret
Abstract
Major trauma induced an immunosuppression, characterized by a decrease in mHLA-DR expression. Importantly, after multivariate regression logistic analysis, persistent decreased expression was assessed to be in relation with the development of sepsis. This is the first study in trauma patients showing a link between the lack of immune recovery and the development of sepsis on the basis of the standardized protocol. Monitoring immune function by mHLA-DR measurement could be useful to identify trauma patients at a high risk of infection.
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