Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
Genome Medicine2010Vol. 2(2), pp. 9–9
Citations Over TimeTop 1% of 2010 papers
Iain J. Gallagher, Camilla Schéele, Pernille Keller, Anders R. Nielsen, Judit Reményi, Christian P. Fischer, Karim Roder, John Babraj, Claes Wahlestedt, György Hutvàgner, Bente Klarlund Pedersen, James A. Timmons
Abstract
We provide evidence that IR in humans may be related to coordinated changes in multiple microRNAs, which act to target relevant signaling pathways. It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner. Thus, miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions.
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