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Systems medicine and integrated care to combat chronic noncommunicable diseases

Genome Medicine2011Vol. 3(7), pp. 43–43

Citations Over TimeTop 1% of 2011 papers

Jean Bousquet, Josep M. Antó, Peter J. Sterk, Ian M. Adcock, Kian Fan Chung, Josep Roca, Àlvar Agustí, Christopher E. Brightling, Anne Cambon‐Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E. Antonarakis, A. Avignon, Andrea Ballabio, Eugenio Baraldi, Baranov Aa, Thomas Bieber, Joël Bockaert, Samir K. Brahmachari, Christian Brambilla, J. Bringer, M. Dauzat, Ingemar Ernberg, Leonardo M. Fabbri, Philippe Froguel, David J. Galas, Takashi Gojobori, Peter Hunter, Christian Jørgensen, F. Kauffmann, Philippe Kourilsky, M. L. Kowalski, Doron Lancet, Claude Le Pen, Jacques Mallet, Bongani M. Mayosi, Jacques Mercier, Andres Metspalu, Joseph H. Nadeau, Grégory Ninot, Denis Noble, Mehmet Öztürk, Susanna Palkonen, Christian Préfaut, Klaus F. Rabe, Éric Renard, Richard Roberts, Boleslav Samolinski, Holger J. Schünemann, Hans‐Uwe Simon, Marcelo B. Soares, Giulio Superti‐Furga, Jesper Tegnér, Sergio Verjovski‐Almeida, P.E. Wellstead, Olaf Wolkenhauer, Emiel F.�M. Wouters, Rudi Balling, Anthony J. Brookes, Dominique Charron, Christophe Pison, Chen Zhu, Leroy Hood, Charles Auffray

Abstract

We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.

Citations Over TimeTop 1% of 2011 papers

Abstract

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