A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis
Genome Medicine2012Vol. 4(12), pp. 103–103
Citations Over TimeTop 10% of 2012 papers
Raymond J. Louie, Jingyu Guo, John Rodgers, Rick White, Najaf A. Shah, Silvère Pagant, Peter Kim, Michael Livstone, Kara Dolinski, Brett A. McKinney, Jeong S. Hong, Eric J. Sorscher, Jennifer Bryan, Elizabeth A. Miller, John L. Hartman
Abstract
We propose phenomic analysis of Yor1-[increment]F as a model for investigating gene interaction networks that can modulate cystic fibrosis disease severity. Although the clinical relevance of the Yor1-[increment]F gene interaction network for cystic fibrosis remains to be defined, the model appears to be informative with respect to human cell models of CFTR-[increment]F. Moreover, the general strategy of yeast phenomics can be employed in a systematic manner to model gene interaction for other diseases relating to pathologies that result from protein misfolding or potentially any disease involving evolutionarily conserved genetic pathways.
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