MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32
Genome Medicine2013Vol. 5(1), pp. 2–2
Citations Over TimeTop 10% of 2013 papers
Andrew D. Kelly, Benjamin Haibe‐Kains, Katherine A. Janeway, Katherine E. Hill, Eleanor Howe, Jeffrey D. Goldsmith, Kyle C. Kurek, Antonio R. Pérez‐Atayde, Nancy Francoeur, Jian‐Bing Fan, Craig April, Hal E. Schneider, Mark C. Gebhardt, Aedín C. Culhane, John Quackenbush, Dimitrios Spentzos
Abstract
Formalin-fixed, paraffin-embedded tissue-derived miRNA patterns are a powerful prognostic tool for risk-stratified osteosarcoma management strategies. Combined miRNA and mRNA analysis supports a possible role of the 14q32 locus in osteosarcoma progression and outcome. Our study creates a paradigm for formalin-fixed, paraffin-embedded-based miRNA biomarker studies in cancer.
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