Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma
Genome Medicine2013Vol. 5(2), pp. 15–15
Citations Over TimeTop 10% of 2013 papers
Matthias Lechner, Tim R. Fenton, James D. West, Gareth A. Wilson, Andrew Feber, Stephen Henderson, Christina Thirlwell, Harpreet Dibra, Amrita Jay, Lee M Butcher, Ankur Chakravarthy, Fiona Gratrix, Nirali M. Patel, Francis Vaz, Paul O’Flynn, Nicholas Kalavrezos, Andrew E. Teschendorff, Chris Boshoff, Stephan Beck
Abstract
Our data establish that archival FFPE tissue is very suitable for this type of methylome analysis, and suggest that HPV modulates the HNSCC epigenome through hypermethylation of Polycomb repressive complex 2 target genes such as cadherins, which are implicated in tumor progression and metastasis.
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