The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal
Journal of Biology2004Vol. 3(4), pp. 15–15
Citations Over TimeTop 10% of 2004 papers
Jens Böse, Achim D. Gruber, Laura Helming, Schiebe Stefanie, Ivonne Wegener, Martin Hafner, Beales Marianne, Frank Köntgen, Andreas Lengeling
Abstract
Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell removal. Ptdsr may thus have a novel, unexpected developmental function as an important differentiation-promoting gene. Moreover, Ptdsr is not required for apoptotic cell clearance by macrophages but seems to be necessary for the regulation of macrophage cytokine responses. These results clearly contradict the current view that the phosphatidylserine receptor primarily functions in apoptotic cell clearance.
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