Reference-guided de novo assembly approach improves genome reconstruction for related species
BMC Bioinformatics2017Vol. 18(1), pp. 474–474
Citations Over TimeTop 10% of 2017 papers
Abstract
The combination of reference mapping and de novo assembly provides a powerful tool to improve genome reconstruction by integrating information of a related genome. Our extension of the reference-guided de novo assembly approach enables the application of this strategy not only within but also between related species. Finally, the evaluation of genome assemblies is often not straight forward, as the truth is not known. Thus one should always use a combination of evaluation metrics, which not only try to assess the continuity but also the accuracy of an assembly.
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