Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer
Journal of Experimental & Clinical Cancer Research2021Vol. 40(1), pp. 307–307
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Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Dickinson, Jasreman Dhillon, Yang Li, Jun‐Li Luo
Abstract
Our study suggests that INMT drives PCa castration resistance through detoxification of anticancer metabolites, targeting INMT or its regulator SMYD3 or/and its methylation metabolites represents an effective therapeutic avenue for CRPC treatment.
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