Cell-lineage heterogeneity and driver mutation recurrence in pre-invasive breast neoplasia
Genome Medicine2015Vol. 7(1), pp. 28–28
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Ziming Weng, Noah Spies, Shirley Zhu, Daniel E. Newburger, Dorna Kashef-Haghighi, Serafim Batzoglou, Arend Sidow, Robert B. West
Abstract
Our analyses demonstrate that multi-sample phylogenetic inference provides insights on the origin of driver mutations, lineage heterogeneity of neoplastic proliferations, and the relationship of genomically aberrant neoplasias with the primary tumors. PIK3CA driver mutations may be comparatively benign inducers of cellular proliferation.
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