Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro
Stem Cell Research & Therapy2013Vol. 4(2), pp. 34–34
Citations Over TimeTop 1% of 2013 papers
Ying Zhou, Huitao Xu, Wenrong Xu, Bingying Wang, Huiyi Wu, Yang Tao, Bin Zhang, Mei Wang, Fei Mao, Yongmin Yan, Shuo Gao, Hongbing Gu, Wei Zhu, Hui Qian
Abstract
The results in the present study indicate that hucMSC-ex can repair cisplatin-induced AKI in rats and NRK-52E cell injury by ameliorating oxidative stress and cell apoptosis, promoting cell proliferation in vivo and in vitro. This suggests that hucMSC-ex could be exploited as a potential therapeutic tool in cisplatin-induced nephrotoxicity.
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