Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells
Stem Cell Research & Therapy2013Vol. 4(5), pp. 125–125
Citations Over TimeTop 10% of 2013 papers
Andreia Ribeiro, Paula Laranjeira, Sandrine Mendes, Isabel Velada, Cristiana Leite, Pedro Andrade, Francisco dos Santos, Ana Henriques, Mário Grãos, Carla M. P. Cardoso, António Martinho, M Pais, Cláudia L. da Silva, Joaquim M. S. Cabral, Hélder Trindade, Artur Paiva
Abstract
Overall, UCM-, BM- and AT-derived MSCs hamper T cell, B cell and NK cell-mediated immune response by preventing their acquisition of lymphoblast characteristics, activation and changing the expression profile of proteins with an important role in immune function, except UCM-MSCs showed no inhibitory effect on B cells under these experimental conditions. Despite the similarities between the three types of MSCs evaluated, we detect important differences that should be taken into account when choosing the MSC source for research or therapeutic purposes.
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