Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
Stem Cell Research & Therapy2013Vol. 4(6), pp. 146–146
Citations Over TimeTop 10% of 2013 papers
Panhong Fan, Shujun Fan, Huan Wang, Jun Mao, Yu Shi, Mohammed Mohammed Ibrahim, Wei Ma, Xiaotang Yu, Zhenhuan Hou, Bo Wang, Lianhong Li
Abstract
We demonstrated for the first time that genistein inhibits BCSCs by down-regulating Hedgehog-Gli1 signaling pathway. These findings provide support and rationale for investigating the clinical application of genistein in treating breast cancer, and specifically by targeting breast cancer stem cells.
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