Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms
Stem Cell Research & Therapy2014Vol. 5(1), pp. 5–5
Citations Over TimeTop 10% of 2014 papers
Diana S. Nascimento, Diogo Mosqueira, Luís Moura Sousa, Mariana Pires Teixeira, Mariana Filipe, Tatiana P. Resende, Francisca Araújo, Mariana Valente, Joana M. Almeida, José Paulo Martins, Jorge M. Santos, Rita N. Bárcia, Pedro E. Cruz, Hélder Cruz, Perpétua Pinto‐do‐Ó
Abstract
UCX® preserve cardiac function after intramyocardial transplantation in a MI murine model. The cardioprotective effects of UCX® were attributed to paracrine mechanisms that appear to enhance angiogenesis, limit the extent of the apoptosis, augment proliferation, and activate a pool of resident CPCs. Overall, these results suggest that UCX® should be considered an alternative cell source when designing new therapeutic approaches to treat MI.
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