Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations
Stem Cell Research & Therapy2014Vol. 5(3), pp. 79–79
Citations Over TimeTop 10% of 2014 papers
Robert C. Rennert, Michael Sorkin, Michael Januszyk, Dominik Duscher, Revanth Kosaraju, Michael T. Chung, James Lennon, Anika Radiya-Dixit, Shubha Raghvendra, Zeshaan N. Maan, Michael S. Hu, Jayakumar Rajadas, Mélanie Rodrigues, Geoffrey C. Gurtner
Abstract
Perturbations in specific cellular subpopulations, visible only on a single-cell level, represent a previously unreported mechanism for the dysfunction of diabetic ASCs. These data suggest that the utility of autologous ASCs for cell-based therapies in patients with diabetes may be limited and that interventions to improve cell function before application are warranted.
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