TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway
Stem Cell Research & Therapy2014Vol. 5(4), pp. 104–104
Citations Over TimeTop 15% of 2014 papers
Catherine Sullivan, Ryan M. Porter, Chris H. Evans, Thomas Ritter, Georgina Shaw, Frank Barry, Mary Murphy
Abstract
These data show that murine MSCs from different genetic backgrounds may be influenced by an inflammatory milieu in a manner that is not mediated by NF-κB, as is the case for human MSCs. This is not mediated by NF-κB. These findings are important and should influence how in vivo trials of murine MSCs are interpreted and the future development of pre-clinical studies in inflammatory diseases.
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