Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation
Stem Cell Research & Therapy2014Vol. 5(6), pp. 140–140
Citations Over TimeTop 10% of 2014 papers
Abstract
Our findings suggest that MSCs exist in a state of arrested autophagy with high autophagosome accumulation and are poised to rapidly undergo autophagic degradation. This phenotype is highly sensitive, and a balance of autophagy appears to be key in efficient MSC differentiation and function, as evidenced by our results implicating autophagic flux in early osteogenesis and adipogenesis.
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