Results of a Randomized Study of Preradiation Chemotherapy Versus Radiotherapy Alone for Nonmetastatic Medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children’s Cancer Study Group PNET-3 Study
Journal of Clinical Oncology2003Vol. 21(8), pp. 1581–1591
Citations Over TimeTop 10% of 2003 papers
Roger Taylor, Clifford C. Bailey, Kath Robinson, Claire Weston, David W. Ellison, James W. Ironside, Helen Lucraft, Richard J. Gilbertson, Diana Tait, David Walker, Barry Pizer, John Imeson, L. S. Lashford
Abstract
This is the first large multicenter randomized study to demonstrate improved EFS for chemotherapy compared with RT alone. It is anticipated that this regimen could reduce ototoxicity and nephrotoxicity compared with cisplatin-containing schedules. The importance of avoiding interruptions to RT has been confirmed.
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