Increased Epidermal Growth Factor Receptor Gene Copy Number Is Associated With Poor Prognosis in Head and Neck Squamous Cell Carcinomas
Journal of Clinical Oncology2006Vol. 24(25), pp. 4170–4176
Citations Over TimeTop 1% of 2006 papers
Christine H. Chung, Kim Ely, Loris McGavran, Marileila Varella‐Garcia, Joel S. Parker, Natalie B. Parker, Carolyn Jarrett, Jesse Carter, Barbara A. Murphy, James L. Netterville, Brian B. Burkey, Robert J. Sinard, Anthony J. Cmelak, Shawn Levy, Wendell G. Yarbrough, Robbert J.C. Slebos, Fred R. Hirsch
Abstract
High EGFR gene copy number by FISH is frequent in HNSCC and is a poor prognostic indicator. Additional investigation is indicated to determine the biologic significance and implications for EGFR inhibitor therapies in HNSCC.
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