Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer
Journal of Clinical Oncology2008Vol. 27(2), pp. 186–192
Citations Over TimeTop 1% of 2008 papers
Paul Salama, Michael Phillips, Fabienne Grieu, M. J. Morris, Nikolajs Zeps, David Joseph, Cameron Platell, Barry Iacopetta
Abstract
FOXP3(+) Treg density in normal and tumor tissue had stronger prognostic significance in colorectal cancer compared with CD8(+) and CD45RO(+) lymphocytes. The finding of improved survival associated with a high density of tumor-infiltrating FOXP3(+) Tregs in colorectal cancer contrasts with several other solid cancer types. The inclusion of FOXP3(+) Treg density may help to improve the prognostication of early-stage colorectal cancer.
Related Papers
- → IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3(2015)126 cited
- → Applications of tissue microarray technology in immunohistochemistry: A study on c-kit expression in small cell lung cancer(2004)16 cited
- → The role of Foxp3 in Treg homeostatic proliferation: Necessary for nTregs, but insufficient for iTregs. (LYM3P.734)(2014)
- A Simple Making Method of Tissue Microarray and Validation Study on Immunohistochemistry(2007)
- A validation study on tissue microarrays(2005)