Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma
Journal of Clinical Oncology2013Vol. 31(26), pp. 3212–3218
Citations Over TimeTop 1% of 2013 papers
Tracy T. Batchelor, Paul Mulholland, Bart Neyns, Burt Nabors, Mario Campone, Antje Wick, Warren Mason, Tom Mikkelsen, Surasak Phuphanich, Lynn S. Ashby, John DeGroot, Rao Gattamaneni, Lawrence Cher, Mark Rosenthal, Franz Payer, Juliane M. Jürgensmeier, Rakesh K. Jain, A. Gregory Sorensen, John Xu, Qi Liu, Martin J. van den Bent
Abstract
This study did not meet its primary end point of PFS prolongation with cediranib either as monotherapy or in combination with lomustine versus lomustine in patients with recurrent glioblastoma, although cediranib showed evidence of clinical activity on some secondary end points including time to deterioration in neurologic status and corticosteroid-sparing effects.
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