Randomized, Controlled Trial of Metformin for Obesity and Insulin Resistance in Children and Adolescents: Improvement in Body Composition and Fasting Insulin
The Journal of Clinical Endocrinology & Metabolism2006Vol. 91(6), pp. 2074–2080
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Shubha Srinivasan, Geoffrey Ambler, Louise A. Baur, Sarah P. Garnett, Mirijana Tepsa, Fabian Yap, Glenn M. Ward, Christopher T. Cowell
Abstract
Metformin therapy for obese insulin-resistant pediatric patients results in significant improvement in body composition and fasting insulin. Although improvement in Si was noted in many individuals, Si was a less useful parameter for analysis of group data, possibly because of effects of variable compliance and changing Si during puberty.
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