A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study
The Journal of Clinical Endocrinology & Metabolism2015Vol. 100(6), pp. 2339–2346
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Darshana Durup, Henrik L. Jørgensen, Jane Christensen, Anne Tjønneland, Anja Olsen, Jytte Halkjær, Bent Lind, Anne‐Marie Heegaard, Peter Schwarz
Abstract
In this large observational study, low and high levels of 25(OH)D were associated with cardiovascular disease, stroke, and acute myocardial mortality in a nonlinear, reverse J-shaped manner, with the highest risk at lower levels. Whether this was a causal or associational finding cannot be determined from our data. There is a need for randomized clinical trials that include information on the effects of 25(OH)D levels greater than 100 nmol/L.
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