Identification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling
Neurology Neuroimmunology & Neuroinflammation2025Vol. 12(4), pp. e200403–e200403
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Martin Guillemaud, Mario Chávez, Firas Kobeissy, Annamaria Vezzani, Anthony D. Jimenez, Maysaa Basha, Ayush Batra, Sophie Demeret, Onome Eka, Krista Eschbach, Brandon Foreman, Nicolas Gaspard, Elizabeth E. Gerard, Teneille Gofton, Hiba A. Haider, Stephen Hantus, Charles L. Howe, Amy C. Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Karnig Kazazian, Minjee Kim, Yi‐Chen Lai, Clémence Marois, Andrew L. Mellor, Wazim Mohamed, M. Morales, Cederic M. Pimentel, Alexandra Martín Ramírez, Claude Steriade, Aaron F. Struck, Olga Taraschenko, Nathan Torcida, Mark S. Wainwright, Ji Yeoun Yoo, Kevin Wang, Vincent Navarro, Lawrence J. Hirsch, Aurélie Hanin
Abstract
The identification of distinct inflammatory subgroups in c-NORSE suggests that variations in the underlying immune mechanisms contribute to differential treatment responses. These findings underscore the importance of personalized therapeutic strategies, potentially targeting specific inflammatory pathways, to optimize clinical outcomes in this challenging condition.
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