Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials
Neurology2017Vol. 89(18), pp. 1915–1922
Citations Over TimeTop 10% of 2017 papers
Ruben P. A. van Eijk, Ashley Jones, William Sproviero, Aleksey Shatunov, Pamela J. Shaw, P. Nigel Leigh, Carolyn Young, Christopher E. Shaw, Gabriele Mora, Jessica Mandrioli, Giuseppe Borghero, Paolo Volanti, Frank P. Diekstra, Wouter van Rheenen, Esther Verstraete, Marinus J.C. Eijkemans, Jan H. Veldink, Adriano Chiò, Ammar Al‐Chalabi, Leonard H. van den Berg, Michael A. van Es, For UKMND-LiCALS and LITALS Study Group, UKMND-LiCALS and LITALS Study Group, Christopher Allen, Carl Counsell, Amanda Farrin, Ammar Al‐Chalabi, Brian Dickie, Joanna Kelly, P N Leigh, Caroline Murphy, C. Payán, Gemma Reynolds, Pamela J. Shaw, I Nick Steen, M Thornhill, Justin S. Waters, John Zajicek, P N Leigh, A Al-Chalabi, Pamela J. Shaw, Carolyn Young, M Thornhill, I N Steen, Caroline Murphy, Karen Morrison, Somendra Kumar Dhariwal, R. W. Hornabrook, L. Savage, David J. Burn, Tien K. Khoo, Joanna Kelly, Caroline Murphy, A Al-Chalabi, Anne H. Dougherty, P. Nigel Leigh, Lokesh Wijesekera, M Thornhill, Cathy Ellis, Azman Ali Raymond, Kathleen O’Hanlon, JN Panicker, L Pate, Priscilla Ray, Lynne Wyatt, Carolyn Young, Larry J. Copeland, J. Ealing, Hisham Hamdalla, Iracema Leroi, Caroline Murphy, Fiadhnait O’Keeffe, E Oughton, Lillian Partington, Phyllis G. Paterson, Dennis J. Rog, A Sathish, David Sexton, Jeff Smith, H Vanek, Steve Hatfield Dodds, Timothy L. Williams, I N Steen, Janine Clarke, Chinea Eziefula, Robert Howard, Richard W. Orrell, Katie Sidle, Robin N. Sylvester, Whitney Barrett, Charlotte Merritt, Kevin Talbot, Martin R. Turner, C Whatley, Courtney Williams, John E. Williams, C Cosby, C. Oliver Hanemann, I Imam, Ceri Phillips, L Timings, Skye Crawford, Channa Hewamadduma, Rachel Hibberd, Hannah Hollinger, Christopher McDermott, Gordon B. Mills, Muhammad Rafiq, Pamela J. Shaw, Albert A. Taylor, E Waines, Tamara Walsh, Robert Addison–Jones, Julie Birt, M Hare, Tabassum Majid, Rosanna Tortelli, Eustachio D’Errico, Ilaria Bartolomei, Elena Barbarossa, B. Depau, E Costantino, Emanuele D’Amico, Antonino Uncini, C. Manzoli, R. Quatrale, Elisabetta Sette, E. Montanari, M. Merello, Davide Zarcone, Massimo Mascolo, M. Vignolo, Sonia Messina, Claudia Morelli, Kalliopi Marinou, Laura Papetti, Christian Lunetta, Ksenija Gorni, D. De Cicco, Carmela Pipia, Patrizia Sola, Eleni Georgoulopoulou, Anna Sagnelli, Gioacchino Tedeschi, Gaia Donata Oggioni, Nicola Nasuelli, Carla D’Ascenzo, Valentina Cima, Marina Aiello, Romana Rizzi, Erminia Rinaldi, Marco Luigetti, Amelia Conte, A. Torzini, G. Greco, Roberto Mutani, Giuseppe Fuda, Marina Tommasi
Abstract
This study incorporated genetic data into past ALS trials to determine treatment effects in a genetic post hoc analysis. Our results suggest that we should reorient our strategies toward finding treatments for ALS, start focusing on genotype-targeted treatments, and standardize genotyping in order to optimize randomization and analysis for future clinical trials.
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