Unique white matter structural connectivity in early-stage drug-naive Parkinson disease
Neurology2019Vol. 94(8), pp. e774–e784
Citations Over TimeTop 10% of 2019 papers
Virendra Mishra, Karthik Sreenivasan, Zhengshi Yang, Xiaowei Zhuang, Dietmar Cordes, Zoltán Mari, Irene Litvan, Hubert H. Fernandez, David Eidelberg, Aaron Ritter, Jeffrey L. Cummings, Ryan R. Walsh
Abstract
By minimizing variance in anatomical connectivity, this study found the presence of a novel WM structural connectome in early PD that correlated with clinical symptoms, despite the lack of a priori analytic assumptions. This included the novel finding of increased structural connectivity between known PD-relevant brain regions. The current study provides a framework for further investigation of WM structural changes underlying the clinical and pathologic heterogeneity of PD.
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