Notch signaling: control of cell communication and cell fate
Development2004Vol. 131(5), pp. 965–973
Citations Over TimeTop 1% of 2004 papers
Abstract
Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.
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