Polycomb/Trithorax response elements and epigenetic memory of cell identity
Development2006Vol. 134(2), pp. 223–232
Citations Over TimeTop 1% of 2006 papers
Abstract
Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal pieces. Just a few hundred base pairs long, these elements can remember and maintain the active or silent transcriptional state of their associated genes for many cell generations, long after the initial determining activators and repressors have disappeared. Recently, substantial progress has been made towards understanding the nuts and bolts of PRE/TRE function at the molecular level and in experimentally mapping PRE/TRE sites across whole genomes. Here we examine the insights, controversies and new questions that have been generated by this recent flood of data.
Related Papers
- → Maternal care, the epigenome and phenotypic differences in behavior(2007)265 cited
- → Epigenetic mediators and consequences of excessive alcohol consumption(2017)42 cited
- → Nutrition and the Epigenome(2012)33 cited
- → Nutrition, epigenetics and health through life(2017)14 cited
- → The Ability of Nutrition to Mitigate Epigenetic Drift: A Novel Look at Regulating Gene Expression(2021)1 cited