Hippo signaling: growth control and beyond
Citations Over TimeTop 1% of 2010 papers
Abstract
The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Here, we review recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development. We also discuss the expanding diversity of Hippo signaling functions during development, discoveries that shed light on a complex regulatory system and provide exciting new insights into the elusive mechanisms that regulate organ growth and regeneration.
Related Papers
- → Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo(2024)3 cited
- → The Hippo–YAP pathway in organ size control and tumorigenesis: an updated version(2010)1,133 cited
- Mechanism of Temperature Regulator and Application of Home Produced Regulator(2006)
- → Abstract IA04: Regulation of the Hippo pathway in cancer(2020)
- → P04.20 The role of YAP in Glioblastoma cell lines(2021)