A conserved germline multipotency program
Development2010Vol. 137(24), pp. 4113–4126
Citations Over TimeTop 10% of 2010 papers
Abstract
The germline of multicellular animals is segregated from somatic tissues, which is an essential developmental process for the next generation. Although certain ecdysozoans and chordates segregate their germline during embryogenesis, animals from other taxa segregate their germline after embryogenesis from multipotent progenitor cells. An overlapping set of genes, including vasa, nanos and piwi, operate in both multipotent precursors and in the germline. As we propose here, this conservation implies the existence of an underlying germline multipotency program in these cell types that has a previously underappreciated and conserved function in maintaining multipotency.
Related Papers
- → The Drosophila cyst stem cell lineage(2012)105 cited
- → The Mechanism of Germline Sex Determination in Vertebrates(2016)29 cited
- → Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans(1990)84 cited
- → A Mutation of cdc-25.1 Causes Defects in Germ Cells But Not in Somatic Tissues in C. elegans(2009)18 cited
- → Somatic PI3K activity regulates transition to the spermatocyte stages in Drosophila testis(2017)6 cited