Switching on cilia: transcriptional networks regulating ciliogenesis
Citations Over TimeTop 1% of 2014 papers
Abstract
Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.
Related Papers
- → Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia(2019)77 cited
- → Intraflagellar transport proteins in ciliogenesis of photoreceptor cells(2011)72 cited
- → Dynein-2 Affects the Regulation of Ciliary Length but Is Not Required for Ciliogenesis inTetrahymena thermophila(2008)33 cited
- → Inactivation of Max-interacting Protein 1 Induces Renal Cilia Disassembly through Reduction in Levels of Intraflagellar Transport 20 in Polycystic Kidney(2013)7 cited
- 研究激酶GCK-2及PKG-1對線蟲神經纖毛生成及鞭毛內運輸機制之影響調控(2014)