Transcriptional repressors: multifaceted regulators of gene expression
Development2013Vol. 140(3), pp. 505–512
Citations Over TimeTop 10% of 2013 papers
Abstract
Through decades of research it has been established that some chromatin-modifying proteins can repress transcription, and thus are generally termed 'repressors'. Although classic repressors undoubtedly silence transcription, genome-wide studies have shown that many repressors are associated with actively transcribed loci and that this is a widespread phenomenon. Here, we review the evidence for the presence of repressors at actively transcribed regions and assess what roles they might be playing. We propose that the modulation of expression levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tuning that drives development.
Related Papers
- → The Transcriptional Repressor Domain of Gli3 Is Intrinsically Disordered(2013)6 cited
- → Biological Activity of Mammalian Transcriptional Repressors(2001)17 cited
- Reconstructing repressor protein levels from expression of gene targets in E. Coli.(2006)
- Mutagenic analysis of the role of the PSDTSSK domain of human SLUG protein in its repressor function in breast cancer cells(2007)
- → Regulation of the LEF1 gene's alternative promoter(2010)