Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4
Development1996Vol. 122(8), pp. 2385–2394
Citations Over TimeTop 10% of 1996 papers
Abstract
ABSTRACT Bone morphogenetic protein-4 (BMP-4) is thought to play an important role in early Xenopus development by acting as a ‘ventralizing factor’ and as an epidermal determinant: local inhibition of BMP-4 function in whole embryos causes the formation of an additional dorsal axis, and inhibition of BMP-4 function in isolated ectodermal cells causes the formation of neural tissue. In this paper we describe a homeobox-containing gene whose expression pattern is similar to that of BMP-4, whose expression requires BMP-4 signalling and which, when over-expressed, causes a phenotype similar to that caused by over-expression of BMP-4. We suggest that this gene, which we call Xom, acts downstream of BMP-4 to mediate its effects.
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