The hardwiring of development: organization and function of genomic regulatory systems
Citations Over TimeTop 10% of 1997 papers
Abstract
The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the transcription factors required for the control of each gene constitute its cis-regulatory system. These systems are remarkably complex. Their hardwired internal organization enables them to behave as genomic information processing systems. Developmental gene regulatory networks consist of the cis-regulatory systems of all the relevant genes and the regulatory linkages amongst them. Though there is yet little explicit information, some general properties of genomic regulatory networks have become apparent. The key to understanding how genomic regulatory networks are organized, and how they work, lies in experimental analysis of cis-regulatory systems at all levels of the regulatory network.
Related Papers
- → Genomic Cis-Regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene(1998)685 cited
- → Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus(2017)95 cited
- → Building developmental gene regulatory networks(2009)40 cited
- → Modular cis ‐regulatory logic of yellow gene expression in silkmoth larvae(2019)8 cited
- → Developmental expression of synthetic cis-regulatory systems composed of spatial control elements from two different genes(1996)24 cited