Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development

Citations Over TimeTop 10% of 1997 papers

Abstract

We investigated the function of Lhx2, a LIM homeobox gene expressed in developing B-cells, forebrain and neural retina, by analyzing embryos deficient in functional Lhx2 protein. Lhx2 mutant embryos are anophthalmic, have malformations of the cerebral cortex, and die in utero due to severe anemia. In Lhx2-/- embryos specification of the optic vesicle occurs; however, development of the eye arrests prior to formation of an optic cup. Deficient cellular proliferation in the forebrain results in hypoplasia of the neocortex and aplasia of the hippocampal anlagen. In addition to the central nervous system malformations, a cell non-autonomous defect of definitive erythropoiesis causes severe anemia in Lhx2-/- embryos. Thus Lhx2 is necessary for normal development of the eye, cerebral cortex, and efficient definitive erythropoiesis.

Related Papers

• → Lissencephaly and Other Malformations of Cortical Development: 1995 Update(1995)332 cited
• → Ectopic lens induction in fish in response to the murine homeobox gene Six3(1996)193 cited
• → Neocortex in early mammals and its subsequent variations(2011)58 cited
• → Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex(2022)3 cited
• → Chromosome X and 17-linked lissencephaly (smooth brain) syndromes(1996)2 cited