A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
Citations Over TimeTop 10% of 2002 papers
Abstract
Sonic hedgehog (Shh) is a key signal in the specification of ventral cell identities along the length of the developing vertebrate neural tube. In the presumptive hindbrain and spinal cord, dorsal development is largely Shh independent. By contrast, we show that Shh is required for cyclin D1 expression and the subsequent growth of both ventral and dorsal regions of the diencephalon and midbrain in early somite-stage mouse embryos. We propose that a Shh-dependent signaling relay regulates proliferation and survival of dorsal cell populations in the diencephalon and midbrain. We present evidence that Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction, at least in part, by regulating the ability of dorsal neural precursors to respond to dorsally secreted Wnt mitogens.
Related Papers
- → Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites(1994)446 cited
- → Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate(2018)16 cited
- → Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs(2012)77 cited
- → Sonic hedgehog: a key mediator of anterior-posterior patterning of the limb and dorso-ventral patterning of axial embryonic structures(1994)57 cited
- → Modulation of Early but Not Later Stages of Programmed Cell Death in Embryonic Avian Spinal Cord by Sonic Hedgehog(1999)51 cited