Cyclical fate restriction: a new view of neural crest cell fate specification
Development2021Vol. 148(22)
Citations Over TimeTop 11% of 2021 papers
Robert N. Kelsh, Karen Camargo Sosa, Saeed Farjami, Vsevolod J. Makeev, Jonathan Dawes, Andrea Rocco
Abstract
Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from fully multipotent neural crest cells might occur, progressive fate restriction (PFR) and direct fate restriction, differing in whether partially restricted intermediates were involved. Initially hotly debated, they remain unreconciled, although PFR has become favoured. However, testing of a PFR hypothesis of zebrafish pigment cell development refutes this view. We propose a novel 'cyclical fate restriction' hypothesis, based upon a more dynamic view of transcriptional states, reconciling the experimental evidence underpinning the traditional hypotheses.
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