0 citations
New derivatization for liquid chromatographic resolution of amino acid enantiomers.
Chemical and Pharmaceutical Bulletin1977Vol. 25(4), pp. 847–849
Abstract
A new method for liquid chromatographic resolution of amino acid enantiomers by the formation of diastereomers has been developed. A chiral reagent used for this purpose, (-)-α-methoxy-α-methyl-1-naphthaleneacetic acid (IIb), was readily prepared by fractionally crystallizing the (+)-α-methylbenzylamine salt. The diastereomers formed from amino acid methyl esters and IIb by the N, N'-dicyclohexylcarbodiimide method were efficiently resolved on the normal phase column.
Related Papers
- → Solvent-induced chirality switching in the enantioseparation of regioisomeric hydroxyphenylpropionic acids via diastereomeric salt formation with (1R,2S)-2-amino-1,2-diphenylethanol(2017)12 cited
- → 8.6 Physical Separations: Behavior of Structurally Similar Molecules in the Resolution Processes(2012)10 cited
- → Enantiomeric 2-anilino-2-oxo-1,3,2-oxazaphosphorinanes: Synthesis and NMR-investigation of their non-racemic mixtures(1995)31 cited
- → New Opportunities to Improve the Enantiomeric and Diastereomeric Separations(2018)
- → Physical Separations: The Behaviour of Not Only Structurally Similar Molecules in the Resolution Processes(2022)