Ferulic Acid Supplementation Prevents Trimethyltin-Induced Cognitive Deficits in Mice
Bioscience Biotechnology and Biochemistry2007Vol. 71(4), pp. 1063–1068
Citations Over TimeTop 10% of 2007 papers
Mi Jeong Kim, Soo Jung Choi, Seung-Taik Lim, Hye Kyung Kim, Ho Jin Heo, Eun-Ki Kim, Woo Jin Jun, Hong Yon Cho, Young Jun Kim, Dong-Hoon Shin
Abstract
This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.
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