Low-Molecular-Weight Hyaluronan Permeates through Human Intestinal Caco-2 Cell Monolayersviathe Paracellular Pathway
Bioscience Biotechnology and Biochemistry2008Vol. 72(4), pp. 1111–1114
Citations Over Time
Nozomi Hisada, Hideo Satsu, Akira Mori, Mamoru Totsuka, Jun-ichi Kamei, Takashi Nozawa, Makoto Shimizu
Abstract
The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway.
Related Papers
- → Regulation of Tight-Junction Permeability During Nutrient Absorption Across the Intestinal Epithelium(1995)193 cited
- → Angulin-2/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine(2020)14 cited
- → The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells(2016)8 cited
- → Permeabilization of the Tight Junction: A Perspective for Tissue-Specific Drug Targeting(2011)