Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos
Environmental Health Perspectives2016Vol. 124(11), pp. 1766–1775
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Aaron Lulla, Lisa M. Barnhill, Gal Bitan, Magdalena I. Ivanova, Binh P. Nguyen, Kelley C. O’Donnell, Mark Stahl, Chase Yamashiro, F.-G. Klarner, Thomas Schräder, Alvaro Sagasti, Jeff M. Bronstein
Abstract
These data show that ziram is selectively toxic to DA neurons in vivo, and this toxicity is synuclein-dependent. These findings have important implications for understanding the mechanisms by which pesticides may cause PD. Citation: Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. 2016. Neurotoxicity of the Parkinson disease-associated pesticide ziram is synuclein-dependent in zebrafish embryos. Environ Health Perspect 124:1766-1775; http://dx.doi.org/10.1289/EHP141.
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