Rare, Protein-Altering Variants in AS3MT and Arsenic Metabolism Efficiency: A Multi-Population Association Study
Environmental Health Perspectives2021Vol. 129(4), pp. 47007–47007
Citations Over Time
Dayana Delgado, Meytal Chernoff, Lei Huang, Tong Lin, Lin Chen, Farzana Jasmine, Justin Shinkle, Shelley A. Cole, Karin Haack, Jack W. Kent, Jason G. Umans, Lyle G. Best, Heather H. Nelson, Donald J. Vander Griend, Joseph H. Graziano, Muhammad G. Kibriya, Ana Navas‐Acién, Margaret R. Karagas, Habibul Ahsan, Brandon L. Pierce
Abstract
Rare, protein-altering variants in AS3MT were associated with lower mean DMA%, an indicator of reduced AME. Although a small percentage of the population (0.5-0.7%) carry these variants, they are associated with a 6-10% decrease in DMA% that is consistent across multiple ancestral and environmental backgrounds. https://doi.org/10.1289/EHP8152.
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