Pharmacodynamics of High-Dose Methotrexate in Pediatric Patients
Annals of Pharmacotherapy2002Vol. 36(9), pp. 1344–1350
Citations Over TimeTop 19% of 2002 papers
Abstract
The analysis of high-dose MTX pharmacokinetic/pharmacodynamic relationship to toxicity has led to equations able to predict toxicity that are easily applicable to daily practice. Cp(24h) >3.5 micro mol/L was confirmed as an indicator of high risk of toxicity.
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