Acute Colchicine Intoxication During Clarithromycin Administration
Annals of Pharmacotherapy2004Vol. 38(12), pp. 2074–2077
Citations Over TimeTop 10% of 2004 papers
Florence Rollot, Olivier Pajot, Laurence Chauvelot‐Moachon, Eve M Nazal, Charikleia Kélaïdi, P. Blanche
Abstract
Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. To this end, colchicine should be used with extreme caution in patients receiving P-glycoprotein inhibitors, particularly if they are elderly and/or renally compromised.
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