A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine
PLoS Medicine2008Vol. 5(6), pp. e117–e117
Citations Over TimeTop 18% of 2008 papers
Chun‐Ting Lee, Chen Jia, Teruo Hayashi, Shang‐Yi Tsai, Joseph F. Sanchez, Stacie L. Errico, Rose Amable, Tsung‐Ping Su, Ross H. Lowe, Marilyn A. Huestis, James Shen, Kevin G. Becker, Herbert M. Geller, William J. Freed
Abstract
Our results demonstrate that down-regulation of cyclin A underlies cocaine-induced proliferation inhibition in neural progenitors. The down-regulation of cyclin A is initiated by N-oxidative metabolism of cocaine and consequent ER stress. Inhibition of cocaine N-oxidative metabolism by P450 inhibitors may provide a preventive strategy for counteracting the adverse effects of cocaine on fetal brain development.
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