Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans
PLoS Medicine2014Vol. 11(11), pp. e1001755–e1001755
Citations Over TimeTop 10% of 2014 papers
Nils C. Gassen, Jakob Hartmann, Jürgen Zschocke, Jens Stepan, Kathrin Hafner, Andreas Zellner, Thomas Kirmeier, Lorenz Korbinian Kollmannsberger, Klaus V. Wagner, Nina Dedic, Georgia Balsevich, Jan M. Deussing, Stefan Kloiber, Susanne Lucae, Florian Holsboer, Matthias Eder, Manfred Uhr, Marcus Ising, Mathias V. Schmidt, Theo Rein
Abstract
To our knowledge, these findings provide the first evidence for the molecular mechanism of FKBP51 in priming autophagic pathways; this process is linked to the potency of at least some antidepressants. These newly discovered functions of FKBP51 also provide novel predictive markers for treatment outcome, consistent with physiological and potential clinical relevance. Please see later in the article for the Editors' Summary.
Related Papers
- → Modified Suanzaorentang Had the Treatment Effect for Generalized Anxiety Disorder for the First 4 Weeks of Paroxetine Medication: A Pragmatic Randomized Controlled Study(2017)4 cited
- A control study of paroxetine and Doxepine in the treatment of general anxiety disorder(2006)
- → Is Selective Autophagy Distinct from Starvation-Induced Autophagy?(2016)
- Clinical Observation on Treatment of Depression by Electro-Acupuncture Combined with Paroxetine(2007)
- Autophagy in cancer biology and therapy(2014)