Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis
PLoS Medicine2019Vol. 16(2), pp. e1002744–e1002744
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Ellis Voerman, Susana Santos, Bernadeta Patro-Gołąb, Pilar Amiano, Ferrán Ballester, Henrique Barros, Anna Bergström, Marie‐Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Graham Devereux, Merete Eggesbø, Sandra Ekström, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Keith M. Godfrey, Davide Gori, Veit Grote, Wojciech Hanke, Irva Hertz‐Picciotto, Barbara Heude, Daniel Hryhorczuk, Rae‐Chi Huang, Hazel Inskip, Nina Iszatt, Anne M. Karvonen, Louise C. Kenny, Berthold Koletzko, Leanne K. Küpers, Hanna Lagström, Irina Lehmann, Per Magnus, Renata Majewska, Johanna Mäkelä, Yannis Μanios, Fionnuala M. McAuliffe, Sheila McDonald, John Mehegan, Monique Mommers, Camilla S. Morgen, Trevor A. Mori, George Moschonis, Deirdre Murray, Carol Ní Chaoimh, Ellen A. Nøhr, Anne‐Marie Nybo Andersen, Emily Oken, Adriëtte J. J. M. Oostvogels, Agnieszka Pac, Eleni Papadopoulou, Juha Pekkanen, Costanza Pizzi, Kinga Polańska, Daniela Porta, Lorenzo Richiardi, Sheryl L. Rifas‐Shiman, Luca Ronfani, Ana Cristina Santos, Marie Standl, Camilla Stoltenberg, Elisabeth Thiering, Carel Thijs, Maties Torrent, Suzanne Tough, T. Trnovec, Steve Turner, Lenie van Rossem, Andrea von Berg, Martine Vrijheid, Tanja G. M. Vrijkotte, Jane West, Alet H. Wijga, John Wright, Олександр Звінчук, Thorkild I. A. Sørensen, Debbie A. Lawlor, Romy Gaillard, Vincent W. V. Jaddoe
Abstract
In this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy.
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